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Neurotransmitters are chemicals; signals are transmitted from neuron to the target cell via a synapse through neurotransmitters. Neurotransmitters are associated in the synaptic vesicles congregated in the presynaptic membrane and are released in the synaptic cleft, In the synaptic cleft they attach to the receptors in the postsynaptic membrane.(1)Monoamine transporters are proteins which are found on nerve terminals of noradrenegenic,serotonergic and dopaminergic neurons. They are also part of sodium dependent transporters and have a key role in terminating the released neurotransmitters action in the synaptic cleft. In addition Transporter proteins are important in assimilating monoaminergic innervations as well as being the main target molecules for numerous amount of antidepressive drugs and substances for abuse. Monoamine transporters consists vesicular monoamine transporters (VMAT) and plasma membrane. Monoamine is carried in to the vesicles by the latter non-selectively and dopamine, nor adrenaline and serotonin is transported into vesicles by Na+/Cl- and selectively former. M…
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